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KMID : 0365819720120010197
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Journal of Pusan Medical College
1972 Volume.12 No. 1 p.197 ~ p.206
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The Relation between Serum Ceruloplasmin Level and Hepatic Lesions in the Rats Administered Copper and Carbon Tetrachloride for Long Term
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Abstract
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In this experimental study the author intended to know the relation between serum ceruloplasmin level and liver damage. The animals used were adult rats of both sexes. and were divided into three groups. Each group was divided again into three subgroups. The first, second, and third subgroups belonging to the first group were given copper alone every day for 30, 60 and 90 days, respectively. The first, second, and third subgroups belonging to the second group were given carbon tetrachloride alone every three days for 30, 60 and 90 days, respectively. The first, second, and third subgroups belonging to the third group were given copper every day and carbon tetrachloride every three days for 30, 60 and 90 days, respectively. The serum ceruloplasmin level was measured in the individual rat after the above mention) treatment, and then it was sacrificed for pathological and histochemical observations of the 1 iver.
The results thus obtained were summarized as follows:
1. The serum ceruloplasmin level decreased even in the animals given copper alone every day for 90 days, and their livers showed non-septal fibrosis. The serum ceruloplasmin level decreased in the animals given carbon tetrachloride 20 or 30 times alone or together with copper, and their liver showed septa) fibrosis,
2. The decrease in strum ceruloplasmin level in the experimental animals was almost parallel with the alterative changes of the liver parenchyma and the resulting fibrosis. The serum ceruloplasmin level, therefore, seemed to reflect the parenchyma) damage of the liver.
3. There was parallelism between the activity of acid phosphatase and copper deposition in the liver in the animals given copper alone or together with carbon tetrachloride, and between iron deposition and cirrhosis of the liver in the animals given tetrachloride alone or together with copper.
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